Wednesday, December 16, 2020

Corona Daily 235: Antacid Shortage causes Heartburn


In April this year, developed countries faced shortages of a variety of products. Supermarket shelves were empty of toilet papers. The reason was hoarding, rather than increased use, of toilet paper rolls. Demand for hand sanitisers, masks, bottled water, thermometers suddenly shot up. They were out of stock at different times. One more product has been frequently in short supply.

Antacids.

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Heartburn occurs when acid in the stomach flows up into the esophagus (food pipe) and causes pain that moves from the stomach to the chest. For a variety of symptoms such as heartburn, acid reflux, indigestion, gases, bloating, stomach ulcers and gastritis; antacids are offered as a medical remedy. They contain calcium, magnesium, aluminum salts which work to neutralize the acids in the stomach. Antacids are sold in a variety of forms – tablets, liquids or chewable gummies. Gelusil, Eno, Gaviscon (India), Tums, Pepcid and Famotidine (USA) are well known antacid brands.

What causes heartburn or acidity? The list is long: Fried and fatty foods. Acidic foods (like lemons or tomatoes). Chocolate. Alcohol. Peppermint. Caffeine. Sodas (carbonated drinks). Acidic juices. Table salt. Spicy food.

In short, any food and drink we love is liable to give us some form of acidity, indigestion or heartburn. Mental stress can also cause all of these symptoms.

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In April, as we all remember, the world was frantically conducting studies to find out what may work against the coronavirus. In a hospital, a set of researchers administered nine times the usual dose of famotidine (antacid) intravenously to covid patients. All 187 patients were in a critical stage. The crude study found out that covid-19 patients on famotidine were dying at a rate of 14%, those without at 27%. After the news of the study became public, American pharmacies like Walgreens and CVS sold all antacid stocks within two days.

Before that, on 1 April, FDA banned Ranitidine, popularly known as Zantac. It was an easy to buy, over the counter drug. Investigation showed it can cause cancer if stored for a long time before consumption. Americans were asked not to buy Zantac, and throw away whatever stocks they had at home.

Over the next few months, the pandemic stress grew. Diet composition changed dramatically. Working from home and little exercise meant extra kilos that caused heartburn and acid reflux. Under depression and a cloud of fear, people who could afford it increased the consumption of booze, sweets, comfort food, takeaway pizzas and fizzy drinks. Johnson & Johnson, makers of Pepcid, confirmed sales of Tylenol, Pepcid and other antacids grew by 30%.

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India is known as the pharmacy to the world. Antacid tablets are unusually cheap – one US dollar can buy 200 tablets in India.  Sun Pharma, Cadila, Torrent sell about 70 million tablets annually. Thanks to Trump who was busy advertising a variety of quack treatments, India managed to produce and export large quantities of hydroxychloroquine (now rejected by both FDA and WHO), paracetamol and famotidine. In October, when Trump was infected, White House confirmed he was taking famotidine along with Zinc and Vitamin D. After that announcement the sales and shortages of famotidine suddenly grew. (Don’t forget 74 million Americans voted for Trump).

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The November elections caused unbearable stress and fear about Trump not winning (Trump supporters) and fear about Trump winning (Biden supporters). With the winter wave in North America and Europe, stress levels are sufficiently high for antacids to be out of stock once again.

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Antacids may have only a short-term effect. Several stomach discomforts are aggravated by continuously thinking about them. In my view, it is better to accept the reality of the pandemic stress and lifestyle, learn to live with the heartburn, rather than get addicted to any form of antacids.

Ravi 

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