Richard Fisher is a science journalist with the BBC.
In May, he came across a tweet of an Oxford University philosopher who had
enrolled for the vaccine trial. Fisher, his journalistic curiosity aroused,
signed up on the website, filled out a questionnaire about his medical history
and got an appointment in St George’s Hospital in south London.
On 26 June, a masked hospital attendant holding up a
sign “vaccine trial” welcomed him. In the neurology ward, now redone for the
Oxford trial, Matthew Snape, a leading scientist made a presentation on a large
screen. Snape explained what the volunteers can and can’t do, the science
behind the vaccines, possible side-effects, experimental and control groups.
Snape also explained how they took a flu virus from a chimpanzee
and genetically altered it to make proteins from the Covid-19 virus.
The volunteers were briefed about the risks, and the
theoretical possibility of the vaccine making the effects of the coronavirus
worse.
After the video presentation, Fisher was questioned
in-depth about his medical history, if he had symptoms of coronavirus. He gave
his blood sample, and signed a consent form with various undertakings, e.g. he
won’t donate blood in the next twelve months. (A woman, as I wrote yesterday,
must undertake not to be pregnant in the next twelve months). One line on the
form says: ‘I agree that the samples collected will be considered a gift to
Oxford University.’ This made Fisher smile knowing some participants would be
asked to give stool samples.
*****
A week later, on 3 July, Fisher once again appeared in
the windowless room at St George’s. Once again, they went through his medical
history, then took more blood. Galiza, a pediatric vaccine researcher came in
with a vial. Smiling through her mask, she injected the trial vaccine in
Fisher’s arm. Neither Fisher nor Galiza knew whether it was the test vaccine
ChAdOx1 nCoV-19, or the dummy vaccine. (The trial is using MenACWY vaccine
given against meningitis or sepsis as a control vaccine.)
Fisher became part of the 10,000 volunteers who risk
encountering the killer virus for the greater good of the world. Apart from the
UK, similar large-scale trials are happening in Brazil and South Africa, with
USA next on the agenda.
*****
Seven days later, on 10 July, Fisher needed to rub his
tonsils with a cotton bud swab, without touching his teeth or tongue, and then
stick the same stick deep up his nose. Once the uncomfortable nasal swab was
taken, he sealed it and placed it into a security-sealed box “Biological
Substance Category B”. Royal Mail UK has provided those special boxes for home
tests. Along with the swab, he also answered a questionnaire about his behavior
in the previous week. Did he use public transport? Did he spend more than five
hours with anyone from outside his family? etc.
A few days later, he got a text message saying he
tested negative.
*****
Richard Fisher is required to repeat this routine once
every week for at least four months, and visit the hospital regularly for blood
tests over the next 12 months.
His firsthand account gives us some idea about the
tediousness of the vaccine process. Before developing a level of confidence to
give a shot in the arms of a few billion, the world will need lots of data and lots
of patience.
Ravi